Liping Feng
Associate Professor of Obstetrics and Gynecology
Contact
feng0007@mc.duke.edu(919) 613-1459
Chesterfield Building, 701 W Main Street, Durham, 27710
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Liping Feng
Associate Professor of Obstetrics and Gynecology
Liping Feng's lab employs physiological, molecular, and translational approaches to study environmental health, placental biology, fetal programming, and reproductive and maternal health. Dr. Feng has a primary appointment in the Department of Obstetrics and Gynecology of the Duke University School of Medicine and her lab utilizes a wide variety of model systems including primary human trophoblast cells, stem cells, human placental tissue, mice, rats, and rabbits to support this focus. Current projects include 1) studies of the impact of perinatal PFAS exposure on placental function and early programming of fetal development, identifying mechanistic links between altered placental function, fetal growth, and adult health, placental-fetal signaling in modulating fetal immune and brain development; 2) studies of the roles of placental molecular signals in reproduction and neurobehavioral development in offspring using placental specific knockout mouse models.
Projects
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Perinatal PFAS exposure and immunotoxicity in early life
United States
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Drinking Water Contamination in NC: Water Use, Human Health and Going Beyond GenX
United States
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Maternal exposure to e-waste in Guiyu, China and birth outcomes
China
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Effects of perfluorobutane sulfonate (PFBS) exposure on adverse pregnancy outcomes and fetal development
China, United States
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The development of a platform mimicking the human placental barrier
United States
Publications
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Zhu X, Huang Q, Jiang L, Nguyen V-T, Vu T, Devlin G, et al. Longitudinal intravital imaging of mouse placenta. Sci Adv. 2024 Mar 22;10(12):eadk1278.Marchese MJ, Zhu T, Hawkey AB, Wang K, Yuan E, Wen J, et al. Prenatal and perinatal exposure to Per- and polyfluoroalkyl substances (PFAS)-contaminated drinking water impacts offspring neurobehavior and development. Sci Total Environ. 2024 Mar 20;917:170459.Liu Y, Li S, Liu B, Zhang J, Wang C, Feng L. Maternal urban particulate matter (SRM 1648a) exposure disrupted the cellular immune homeostasis during early life: The potential attribution of altered placental transcriptome profile. Sci Total Environ. 2024 Feb 20;912:169432.Yokouchi-Konishi T, Liu Y, Feng L. Progesterone receptor membrane component 2 is critical for human placental extravillous trophoblast invasion. Biol Reprod. 2023 Nov 15;109(5):759–71.
See more publications at Scholars@Duke