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Affiliate Faculty

Georgia Tomaras

Professor (with tenure), Department of Surgery Professor, Department of Immunology Professor, Department of Molecular Genetics and Microbiology
School of Medicine
(919) 681-5598
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Georgia Tomaras

Summary

Dr. Tomaras' overall research program is to understand the cellular and humoral immune response to HIV-1 infection and vaccination that are involved in protection from HIV-1. The research in the Tomaras laboratory centers around three main projects involving 1) antiviral CD8 T cell responses in HIV-1 infection and post vaccination, 2) mucosal and systemic antibody responses to infection and vaccination in both non-human primates and humans and 3) the ontogeny of neutralizing antibodies in HIV-1 infection. Her laboratory is also within the Duke Human Vaccine Institute.

Locations

Projects

Recent Publications

Seaton, KE, Vandergrift, NA, Deal, AW, Rountree, W, Bainbridge, J, Grebe, E, Anderson, DA, Sawant, S, Shen, X, Yates, NL, Denny, TN, Liao, H-X, Haynes, BF, Robb, ML, Parkin, N, Santos, BR, Garrett, N, Price, MA, Naniche, D, Duerr, AC, CEPHIA group, , Keating, S, Hampton, D, Facente, S, Marson, K, Welte, A, Pilcher, CD, Cohen, MS, & Tomaras, GD. (2017, December 21). Computational analysis of antibody dynamics identifies recent HIV-1 infection. JCI insight, 2 (24).
Mayer, KH, Seaton, KE, Huang, Y, Grunenberg, N, Isaacs, A, Allen, M, Ledgerwood, JE, Frank, I, Sobieszczyk, ME, Baden, LR, Rodriguez, B, Van Tieu, H, Tomaras, GD, Deal, A, Goodman, D, Bailer, RT, Ferrari, G, Jensen, R, Hural, J, Graham, BS, Mascola, JR, Corey, L, Montefiori, DC, HVTN 104 Protocol Team, , & and the NIAID HIV Vaccine Trials Network, . (2017, November 14). Safety, pharmacokinetics, and immunological activities of multiple intravenous or subcutaneous doses of an anti-HIV monoclonal antibody, VRC01, administered to HIV-uninfected adults: Results of a phase 1 randomized trial. PLoS medicine, 14 (11), e1002435-.
Li, SS, Kochar, NK, Elizaga, M, Hay, CM, Wilson, GJ, Cohen, KW, De Rosa, SC, Xu, R, Ota-Setlik, A, Morris, D, Finak, G, Allen, M, Tieu, H-V, Frank, I, Sobieszczyk, ME, Hannaman, D, Gottardo, R, Gilbert, PB, Tomaras, GD, Corey, L, Clarke, DK, Egan, MA, Eldridge, JH, McElrath, MJ, Frahm, N, & NIAID HIV Vaccine Trials Network, . (2017, November). DNA Priming Increases Frequency of T-Cell Responses to a Vesicular Stomatitis Virus HIV Vaccine with Specific Enhancement of CD8+ T-Cell Responses by Interleukin-12 Plasmid DNA. Clinical and vaccine immunology : CVI, 24 (11).
Wang, K, Tomaras, GD, Jegaskanda, S, Moody, MA, Liao, H-X, Goodman, KN, Berman, PW, Rerks-Ngarm, S, Pitisuttithum, P, Nitayapan, S, Kaewkungwal, J, Haynes, BF, & Cohen, JI. (2017, October). Monoclonal Antibodies, Derived from Humans Vaccinated with the RV144 HIV Vaccine Containing the HVEM Binding Domain of Herpes Simplex Virus (HSV) Glycoprotein D, Neutralize HSV Infection, Mediate Antibody-Dependent Cellular Cytotoxicity, and Protect Mice from Ocular Challenge with HSV-1. Journal of virology, 91 (19).
Meyerhoff, RR, Scearce, RM, Ogburn, DF, Lockwood, B, Pickeral, J, Kuraoka, M, Anasti, K, Eudailey, J, Eaton, A, Cooper, M, Wiehe, K, Montefiori, DC, Tomaras, G, Ferrari, G, Alam, SM, Liao, H-X, Korber, B, Gao, F, & Haynes, BF. (2017, August). HIV-1 Consensus Envelope-Induced Broadly Binding Antibodies. AIDS research and human retroviruses, 33 (8), 859-868.

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