In this study, researchers conducted a prospective, population based cohort study. The study is divided into two phases. In Phase I, researchers performed a one-year pilot study, establishing the research infrastructure necessary for Phase II, building upon the existing Jubilant First Trust clinical infrastructure, and collecting clinical data and biological samples on 1,000 patients. In Phase II, researchers conducted a four- to five-year prospective, population-based study with collection of clinical data, biological samples and longitudinal follow-up.